Epoetin 2000 IU Injection 1pc

✔️ Uses of Epoetin 2000 IU Injection

Erythropoietin is an effective treatment for anemia associated with chronic kidney disease or cancer chemotherapy.

✔️ How does Epoetin 2000 IU Injection work?

Erythropoietin works by stimulating the bone marrow (soft tissue inside the bones which produces red blood cells) to produce more red blood cells.

✔️ Side Effects of Epoetin 2000 IU Injection

• Common: Headache, dizziness, fever, malaise, arthralgia, hyperkalemia.
• Cardiovascular: Hypertension, palpitations.
• Gastrointestinal: Nausea, vomiting, anorexia, diarrhea.
• Allergic reactions.

✔️ Quick Suggestions:

• Erythropoietin is used to treat anemia associated with chronic kidney disease or cancer chemotherapy. It works by stimulating the production of red blood cells in the body.
• It is administered as a single injection under the skin (subcutaneously).
• Follow your doctor's instructions carefully regarding the dosage and frequency of injections.
• Regular blood tests may be required to monitor hemoglobin levels, blood cell counts, and electrolyte levels such as potassium.
• Blood pressure should be monitored regularly while on this medication.
• Inform your doctor immediately if you experience symptoms of very high blood pressure, including severe headaches, vision problems, nausea, vomiting, or seizures.
• Stop taking Erythropoietin and notify your doctor if you develop shortness of breath or a skin rash.

✔️ Indication of Epoetin 2000 IU Injection

• Anemia is associated with Chronic Renal Failure (CRF), both in patients on dialysis and those not on dialysis.
• Anemia in patients with non-myeloid malignancies undergoing concomitant chemotherapy.
• Anemic patients (hemoglobin >10 to <13 g/dL) are scheduled for elective, non-cardiac, non-vascular surgery to reduce the need for allogeneic blood transfusions.
• Anemia related to therapy with zidovudine in HIV-infected patients.

✔️ Pharmacology

• Epoetin 2000 IU regulates erythropoiesis by stimulating the differentiation and proliferation of erythroid precursors.
• It stimulates the release of reticulocytes into circulation and the synthesis of cellular hemoglobin.
• Recombinant human Epoetin 2000 IU, available as epoetin alfa and epoetin beta, is used in the management of anemias associated with CRF, cancer chemotherapy, and zidovudine therapy in HIV patients.

✔️ Dosage & Administration of Epoetin 2000 IU Injection

• The starting dose for adults is usually 50 to 100 IU/kg three times a week (TIW) by IV or subcutaneous route.
• Maintenance dose must be individualized for each patient, typically ranging from 75 to 150 IU/kg/week.
• Administer intravenously over 1-2 minutes.
• Slow injection over 5 minutes may be beneficial for those experiencing flu-like symptoms.
• Do not administer by intravenous infusion or in conjunction with other drug solutions.

✔️ Interaction

• Haematinics enhance efficiency.
• Increased dose of heparin in patients undergoing dialysis.

✔️ Contraindications

• Uncontrolled hypertension.
• Known hypersensitivity to mammalian cell-derived products.
• History of hypersensitivity to Epoetin 2000 IU or any component of the preparation.

✔️ Pregnancy & Lactation

• Pregnancy Category C. Use during pregnancy only if needed.
• Caution is advised during breastfeeding.

✔️ Precautions & Warnings

• Caution in patients with controlled hypertension, ischaemic vascular disease, history of seizures, or suspected allergy.
• Iron evaluation before and during therapy.
• Virtually all patients will require supplemental iron.
• Overdose effects: Temporary drug therapy withholding if the hemoglobin exceeds the suggested target range.

✔️ Storage Conditions

Store at 2°C to 8°C. Protect from light. Do not freeze. Avoid shaking.